Nikolaos C.George Ph.D. (Nick)

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Nick George has been developing and evaluating biologics-based patent portfolios for more than 25 years. He has devised worldwide patent prosecution strategies and evaluated portfolios involving antibodies, antibody drug conjugates, immuno-oncology, cellular therapeutics (including stem cell, natural killer cell, CAR-T, and induced pluripotent stem cell [iPS] therapeutics), gene therapies, oncolytic viruses, CRISPR (gene editing), antisense and other RNA therapeutics, peptide therapeutics, and companion diagnostics and enzyme replacements, among others.

Nick has developed patent strategies for such marketed products as Fuzeon®, Kynamro®, Fabrazyme®, Syvek®, and Talymed® and for such biologics drug candidates as Celgene and Celularity's cellular therapeutics and Celldex Therapeutics' ErbB3 and KIT antibody clinical candidates. He also has developed patent strategies for such diagnostic products as Phenosense™, GeneSeq™, Replication Capacity™, and the companion diagnostic, Trofile™ (Monogram, now LabCorp).

Nick holds a Ph.D. in genetics from the University of California, Berkeley (1990). Following a postdoctoral fellowship at Columbia University, he joined the legal intern program at his previous firm, during which time he also attended the evening program of Fordham University School of Law.

Experience

  • Celgene acquired by Bristol-Myers Squibb for approximately $74 billionJones Day advised Celgene Corporation (NASDAQ: CELG) in connection with the intellectual property and technology transactions aspects of its cash-and-stock merger with Bristol-Myers Squibb (NYSE: BMY) which has an equity value of approximately $74 billion.
  • Celldex Therapeutics develops worldwide patent portfolios for receptor tyrosine kinase antibody therapeuticsJones Day is developing worldwide patent portfolios for Celldex Therapeutics, Inc.'s receptor tyrosine kinase antibody therapeutics, including anti-ErbB3 and anti-KIT antibody clinical candidates.
  • ToolGen seeks patent protection for CRISPR technologyJones Day is prosecuting patent applications and developing a patent portfolio on behalf of ToolGen, Inc. for CRISPR technology.
  • RaNA Therapeutics (now known as Translate Bio) acquires Shire's messenger RNA therapy platformJones Day acted as IP counsel to RaNA Therapeutics, Inc. (now known as Translate Bio) in connection with its acquisition of Shire Pharmaceuticals' messenger RNA therapy platform (MRT), with lead programs in cystic fibrosis and urea cycle disorders.
  • Celgene develops worldwide patent portfolios covering CAR-T and other cellular therapeuticsJones Day is advising Celgene Corporation in the strategic development of worldwide patent portfolios covering CAR-T and other cellular therapeutics.
  • Celgene develops patent portfolio for anti-CD47 therapeutic antibodiesJones Day represented Celgene Corporation in the development of a portfolio of patents directed to anti-CD47 therapeutic antibodies.
  • Genzyme (Sanofi) develops patent portfolio for antisense drug Kynamro®Jones Day represented Genzyme Corporation (Sanofi) in developing patent portfolios related to the apolipoprotein B-targeting antisense drug, Kynamro® (mipomersen), which was the first antisense drug to reach the market and used for the treatment of homozygous familial hypercholesterolemia.
  • Celgene enters strategic collaboration with MedImmune for hematologic malignanciesJones Day acted as special patent counsel, IP technology transaction counsel, and tax counsel on Celgene Corporation's strategic collaboration with MedImmune regarding human monoclonal antibody MEDI-4736 directed to PD-L1 to allow the immune system to continue to fight blood cancers.
  • Kirin Pharma Kabushiki Kaisha establishes patent portfolio for human LIGHT antibodiesJones Day represented Kirin Pharma Kabushiki Kaisha and Kirin Pharma USA, Inc. in the development of its patent portfolio and prosecution strategies related to human LIGHT antibodies.
  • PDL BioPharma goes head to head against UCB Pharma in patent interference involving reshaped humanized immunoglobulinsJones Day represented PDL BioPharma, Inc. in patent interference against UCB Pharma S.A. involving "reshaped" humanized immunoglobulins.
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